Nucleic acid ppt pdf

Inhibitors of nucleic acid synthesis the antibacterial drugs that inhibit nucleic acid synthesis function by inhibiting 1 dna polymerase and dna helicase or 2 rna polymerase to block replication or transcription, respectively. They are major components of all cells 15% of the cells dry weight. Nucleic acids nucleic acids nucleic acids structures of nucleic acids dna replication rna and transcription nucleotides nucleic acids consist of nucleotides that have a sugar. Nucleotides are the building blocks of nucleic acids. It has many functions in cells, notably acting as the intermediate between dna and proteins. Dna must be replicated accurately in order to ensure the integrity of the genetic code. Describe the makeup of nucleosides, nucleotides, oligonucleotides, and polynucleotides. The bases are divided into purines guanine and adenine and pyrimidines cytosine, thymine, and uracil with. Use the ndb to perform searches based on annotations relating to sequence, structure and function, and to download, analyze, and learn about nucleic acids. Nucleic acids sarote boonseng deoxyribonucleic acid dna ribonucleic acid rna.

Ppt nucleic acids powerpoint presentation free to download id. Nucleotides are composed of a fivecarbon sugar covalently attached to a phosphate group and a base containing nitrogen atoms. Nucleic acidbased diagnostics are a standard central laboratory technique, although simplified nucleic acidbased diagnostics that may be useful in resourcepoor settings are emerging. The adobe flash plugin is needed to view this content. Chapter 8 nucleotides and nucleic acids chapter 8 nucleotides and nucleic acids some basics nucleic acid structure nucleic acid chemistry other functions of nucleotides 8. Kinds of nucleic acids dna deoxyribonucleic acid found only inside the nucleus of the cell. The nucleic acid database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Mitochondrial and chloroplast dna, plasmids and bacterial chromosomes are in circular form.

Nucleic acids may have three or four strands too forming triplex or quadraduplex. Nucleic acids are the main informationcarrying molecules of the cell, and, by directing the process of protein synthesis, they determine the inherited characteristics of every living thing. Pdf saccharomyces cerevisiae is an excellent model organism for the study of eukaryotic genetics. A nucleic acid is a chain of nucleotides which stores genetic information in biological systems.

Dna is identical most energy favorable conformation for double stranded dna to form without antiparallel base pairing this conformation could not exist structure consists of major grooves and minor grooves. Scribd is the worlds largest social reading and publishing site. Friedrich miescher who discovered nucleic acids in 1871. Structural properties of nucleic acid building blocks function of dna and rna dna and rna are chainlike macromolecules that function in the storage and transfer of genetic information.

Nucleic acid amplification is a pivotal process in biotechnology and molecular biology and has been widely used in research, medicine, agriculture and forensics. Dna contains two purine bases adenine and guanine and two pyrimidine bases cytosine and thymine. View and download powerpoint presentations on nucleic acid ppt. Dongyou liu, in molecular medical microbiology second edition, 2015. Structure of dna consists of two strands of nucleotides that form a twisted ladder double helix sugar and phosphate alternate along the sides of the ladder linked by strong covalent bonds pairs of nitrogen bases form the rungs of the ladder linked by weak hydrogen bonds. Source of stored energy transport stored energy carbon skeletons that can be rearranged to form new molecules. The two classes of nucleic acids are dna deoxyribonucleic acid and rna ribonucleic acid. What is nucleic acid and its historical perspective u initially, nucleic acid was known by the term nuclein by friedrich miescher, a 25year old swiss chemist, isolated nuclei from pus cells white blood corpuscles and found that they contained a unknown phosphate. One caveat of using absorbance based measurements of nucleic acid samples is that proteins and reagents. Carbohydrates have the general formula c nh 2o n 3 main roles. Chapter 2 structures of nucleic acids nucleic acids.

Know the three chemical components of a nucleotide. Nucleic acid test an overview sciencedirect topics. Nucleic acid, naturally occurring chemical compound that is capable of being broken down to yield phosphoric acid, sugars, and a mixture of organic bases purines and pyrimidines. In this article we will discuss about the process of biosynthesis of nucleic acids. Nucleic acids are polymers that consist of nucleotide residues. The 4th type of macromolecules the chemical link between generations the source of genetic information in chromosomes what do they do. Identify phosphoester bonding patterns and nglycosidic bonds within nucleotides. The last portion of nucleic acids is the phosphate group.

Compare and contrast ribonucleotides and deoxyribonucleotides. Objectives by the end of lecture the student should. However, there seems to be a certain tendency to confuse nucleic acid template hypotheses with nuclear template hypotheses, where the word nuclear refers to the nucleus of the cell. Nucleic acid terminal protection provides a promising strategy for specific, sensitive detection of the binding events between small molecules and their protein targets, and has been applied in. An introduction dna structure and function dna in all forms of life is a polymer made up of nucleotides containing four major types of heterocylclic nitrogenous bases, adenine, thymine, guanine, and cytosine. Nucleotides and nucleic acids chapter 8 lehninger 5th ed. Replication, repair, and recombinationthe three main processes of dna metabolismare carried out by specialized machinery within the cell. Nucleic acid definition, function and examples biology. Biosynthesis of nucleic acids authorstream presentation.

Dna replication 3 main features of the dna synthesis reaction. Nucleic acid binding under appropriate conditions nucleic acid will bind to matrices. Nucleic acids questions and answers pdf free download in biochemistry mcqs,interview questions,objective questions,multiple choice. The genetic information stored in dna is then transcribed into rna, and the details in rna are then translated for the synthesis of the proteins. Find powerpoint presentations and slides using the power of, find free presentations research about nucleic acid ppt.

Biology is brought to you with support from the amgen foundation. It creates dna and rna, which store the information needed by cells to create proteins. Polar atoms in the ring or attached to the ring are capable of creating hydrogen bonds with polar atoms of other bases. Nucleic acid nucleotides phosphoric acid nucleosides sugar ribose or deoxyribose purine guanine and adenine pyrimidine base cytosine, uracil or thymine 11. Introduction to nucleic acids and their structure the questions and.

Purine aromatic organic compound that consists of a pyrimidine ring and an imadazole ring c3h4n2. Describe the primary structure of dna and rna and secondary and. Planar systems slip between the layers of nucleic acid pairs and disrupt the shape of the helix preference is often shown for the minor or major groove intercalation prevents replication and transcription intercalation inhibits topoisomerase ii see doxorubicin, p. While they have significantly different structures, we can describe both dna and rna as polynucleotides polymers of nucleotides. Ribonucleic acid polymer of nucleic acids polynucleotide functions as template for translating genes into proteins, transfers amino acids to the ribosome site on a growing polypeptide chain, etc. Each nucleotide is put together from three building blocks. Nucleosides in the hierarchy of nucleic acid structure, there are two more levels of nomenclature. Nucleic acid as a vaccine platform technology 6 12 18 2112006 12212006 4272009 8272009 4 m 4142003 122004 20 m 11 m h5 indonesia06 h1 california09 sars genebased delivery including mrna, dna, and vectored approaches selfassembling nanoparticles and vlps. Nucleic acid definition a nucleic acid is the base unit of dna and rna, the substances which make up our genetic code. Welcome to the ndb the ndb contains information about experimentallydetermined nucleic acids and complex assemblies. The group that gives each nucleic acid unit its specificity is the organic base. Nnuucclleeiicc aacciiddss nucleic acids are molecules that store information for cellular growth and reproduction there are two types of nucleic acids. Nucleic acid tests target genes encoding enterotoxins in s.

We now know that nucleic acids are found throughout a cell, not just in the nucleus, the name nucleic acid is still used for such materials. Silica cellulose ion exchange manipulating binding conditions can affect the efficiency of nucleic acid binding rna vs. Dictate aminoacid sequence in proteins give information to chromosomes, which is then passed from parent to offspring what are they made of. A nucleic acid is a polymer in which the monomer units are nucleotides. Nucleic acidbased diagnostics detect the presence of a pathogen either by directly detecting the presence of dna or rna nucleic acids in the host or by first amplifying the pathogen dna or rna. It is also a poly mer of four nucleotides, three of which are the same as in. Nucleic acids are the largest and the most complex organic molecules. Nucleic acid free download as powerpoint presentation. By convention, nucleic acid sequences are written from left to right, from the 5end to the 3end. Over the years, the ndb has developed generalized software. It is also a polymer of four nucleotides, three of which are the same as in dna while the fourth one is slightly different. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. This group is of immense importance, as it is through this group that dna and rna are held together. Nucleic acids ppt free download as powerpoint presentation.

Nucleotides energy rich compounds chemical signals enzyme cofactors nucleic acids dna and rna polymers of nucleotides 3 components nitrogenous base ribose or deoxyribose phosphate bases ribose carbons numbered. Module 14 nucleic acids lecture 36 nucleic acids i nptel. Nucleic acid terminal protection is based on the protection of a nucleic acid from degradation or extension by tethering or modification of the nucleic acid terminus with a small molecule. Introduction to nucleic acids and their structure link. Resulting a repeating sugarphosphate backbone with protruding nitrogenous bases. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Unlike dna, rna is singlestranded and consists of a shorter nucleotide chain.

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